Ziegler, Christian and Graf, Johannes and Faderl, Stefan and Schedlbauer, Jessica and Strieder, Nicholas and Foerstl, Bianca and Spang, Rainer and Bruckmann, Astrid and Merkl, Rainer and Hombach, Sonja and Kretz, Markus (2019) The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis. EMBO REPORTS, 20 (2): e46612. ISSN 1469-221X, 1469-3178
Full text not available from this repository. (Request a copy)Abstract
Several long non-coding RNAs (lncRNAs) act as regulators of cellular homeostasis; however, few of these molecules were functionally characterized in a mature human tissue environment. Here, we report that the lncRNA LINC00941 is a crucial regulator of human epidermal homeostasis. LINC00941 is enriched in progenitor keratinocytes and acts as a repressor of keratinocyte differentiation. Furthermore, LINC00941 represses SPRR5, a previously uncharacterized molecule, which functions as an essential positive regulator of keratinocyte differentiation. Interestingly, 54.8% of genes repressed in SPRR5-deficient epidermal tissue are induced in LINC00941-depleted organotypic epidermis, suggesting a common mode of action for both molecules.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIFFERENTIATION COMPLEX; STEM-CELLS; GENE; P63; PROTEINS; differentiation; epidermis; LINC00941; long non-coding RNA; SPRR5 |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Apr 2020 06:00 |
| Last Modified: | 20 Apr 2020 06:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27635 |
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