Franke, Franziska J. and Arzt, Michael and Kroner, Tanja and Gorski, Mathias and Heid, Iris M. and Boeger, Carsten A. and Jung, Bettina and Zeman, Florian and Stadler, Stefan and Andreae, Axel and Haas, Gerhard and Haas, Sabine and Manz, Jochen and Nusser, Johann and Kreisel, Guenther and Bawidamann, Gerhard and Mader, Frederik and Kisskalt, Susanne and Hartl, Johann and Segiet, Thomas and Gleixner, Christiane and Scholz, Christian and Schober, Monika and Heinrich, Cornelia and Bohnhoff, Thomas and Heilmann, Thomas and Stern, Stefan and Utz, Andreas and Zellner, Georg and Ettl, Werner and Buck, Thomas and Bleek, Rainer and Blaudzun, Ulrich and Neumeier, Simone and Hufnagel, Sarah and Haller, Isabel and Jackermeier, Petra and Obermuller, Sabrina and Ried, Christiane and Hanauer, Ulrike and Sendtner, Barbel and Riewe-Kerow, Natalia and Dumann, Konstantin and Hormann, Britta (2019) Daytime napping and diabetes-associated kidney disease. SLEEP MEDICINE, 54. pp. 205-212. ISSN 1389-9457, 1878-5506
Full text not available from this repository. (Request a copy)Abstract
Background: Diabetes-associated Kidney Disease (DKD) is a common comorbidity in patients with type 2 diabetes. The present study investigates whether daytime sleeping duration in patients, ill with type 2 diabetes, is associated with DKD. Methods: A total of 733 outpatients of the cross-sectional baseline survey of the DIACORE study were analyzed with respect to their self-reported daytime sleeping duration, assessed by a standardized questionnaire. DKD was defined as eGFR <60 ml/min/1.73 m(2) and/or urinary albumin-to-creatinine-ratio (UACR) > 30 mg/g. Results: Mean daytime sleeping duration was 17 +/- 27 min. With increasing daytime sleeping duration a statistically significant decrease in eGFR (p = 0.002) and increase in UACR (p < 0.001) were found, respectively. Prevalence of DKD was significantly higher in patients with longer daytime sleeping duration (31% in patients not napping, 40% in patients napping less than 30 min, 47% in patients napping 30-60 min, 56% in patients napping 60 min or more; p = 0.001). After accounting for known modulators (Age, sex, BMI, waist-hip-ratio, systolic and diastolic blood pressure, physical activity, diabetes duration, HbA1c, homeostasis model assessment (HOMA-Index), nighttime sleeping duration, apnea-hypopnea-index (AHI), Epworth Sleepiness Scale (ESS)), longer daytime sleeping duration was significantly associated with impaired eGFR [B (95% CI) = -0.05 (-0.09; 0.00), p = 0.044] and increased UACR [B (95% CI) = 0.01 (0.01; 0.02), p < 0.001], respectively. Conclusion: Increased daytime sleeping duration is significantly associated with reduced eGFR and higher UACR, independent of known modulators of DKD. The direction of this relationship remains unclear. (c) 2018 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REPORTED SLEEP DURATION; GLOMERULAR-FILTRATION-RATE; RISK-FACTOR; POPULATION; PREVALENCE; ADULTS; APNEALINK(TM); HYPERTENSION; PROTEINURIA; DISORDERS; Diabetes; Sleep duration; Napping; Kidney disease; eGFR; UACR |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien Medicine > Institut für Epidemiologie und Präventivmedizin Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Apr 2020 06:31 |
| Last Modified: | 20 Apr 2020 06:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27638 |
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