Weiss, Annette and Sommer, Grit and Schindera, Christina and Wengenroth, Laura and Karow, Axel and Diezi, Manuel and Michel, Gisela and Kuehni, Claudia E. and Ammann, R. and Scheinemann, K. and Ansari, M. and Popovic, M. Beck and Brazzola, P. and Greiner, J. and Grotzer, M. and Hengartner, H. and Kuehne, T. and Roessler, J. and Schilling, F. and von der Weid, N. (2019) Hearing loss and quality of life in survivors of paediatric CNS tumours and other cancers. QUALITY OF LIFE RESEARCH, 28 (2). pp. 515-521. ISSN 0962-9343, 1573-2649
Full text not available from this repository. (Request a copy)Abstract
PurposeHearing loss, a complication of cancer treatment, may reduce health-related quality of life (HRQoL), especially in childhood cancer survivors of central nervous system (CNS) tumours who often have multiple late effects. We examined the effect of hearing loss on HRQoL in young survivors of CNS and other childhood cancers.MethodsWithin the Swiss Childhood Cancer Survivor Study, we sent questionnaires about hearing loss and HRQoL (KIDSCREEN-27) to parents of survivors aged 8-15years. We stratified the effect of hearing loss on HRQoL by cancer diagnosis, using multivariable logistic regression and adjusting for sociodemographic and clinical factors.ResultsHearing loss was associated with impaired physical well-being [unadjusted estimated differences -4.6 (CI -9.2, -0.1); adjusted -4.0 (CI -7.6, -0.3)] and peers and social support [unadjusted -6.7 (CI -13.0, -0.3); adjusted -5.0 (CI -10.5, 0.9)] scores in survivors of CNS tumours (n=123), but not in children diagnosed with other cancers (all p-values>0.20, n=577).ConclusionClinicians should be alert to signs of reduced physical well-being and impaired relationships with peers. Especially survivors of CNS tumours may benefit most from strict audiological monitoring and timely intervention to mitigate secondary consequences of hearing loss on HRQoL.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHILDHOOD-CANCER; NEUROBLASTOMA; COMPLICATIONS; CHILDRENS; Childhood cancer; Ototoxicity; Swiss Childhood Cancer Survivor Study; Swiss Childhood Cancer Registry; Late effects; Cancer treatment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin Medicine > Institut für Epidemiologie und Präventivmedizin > Medical Sociology |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Apr 2020 06:44 |
| Last Modified: | 20 Apr 2020 06:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27659 |
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