Doron, Hila and Pukrop, Tobias and Erez, Neta (2019) A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis. CANCER RESEARCH, 79 (3). pp. 423-436. ISSN 0008-5472, 1538-7445
Full text not available from this repository. (Request a copy)Abstract
Brain metastases are more common than primary CNS tumors and confer grave prognosis on patients, as existing treatments have very limited efficacy. The tumor microenvironment has a central role in facilitating tumorigenesis and metastasis. In recent years, there has been much progress in our understanding of the functional role of the brain metastatic microenvironment. In this review, we discuss the latest advances in brain metastasis research, with special emphasis on the role of the brain microenvironment and neuroinflammation, integrating insights from comparable findings in neuropathologies and primary CNS tumors. In addition, we overview findings on the formation of a hospitable metastatic niche and point out the major gaps in knowledge toward developing new therapeutics that will cotarget the stromal compartment in an effort to improve the treatment and prevention of brain metastases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CENTRAL-NERVOUS-SYSTEM; BREAST-CANCER CELLS; TUMOR BARRIER PERMEABILITY; CEREBRAL-BLOOD-FLOW; REGULATORY T-CELLS; REACTIVE ASTROCYTES; LUNG-CANCER; IMAGING REVEALS; IMMUNE-RESPONSE; GAP-JUNCTIONS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 Mar 2020 10:09 |
| Last Modified: | 26 Mar 2020 10:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27666 |
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