Stieglitz, David and Lamm, Susanne and Braig, Simone and Feuerer, Lena and Kuphal, Silke and Dietrich, Peter and Arndt, Stephanie and Echtenacher, Bernd and Hellerbrand, Claus and Karrer, Sigrid and Bosserhoff, Anja-Katrin (2019) BMP6-induced modulation of the tumor micro-milieu. ONCOGENE, 38 (5). pp. 609-621. ISSN 0950-9232, 1476-5594
Full text not available from this repository. (Request a copy)Abstract
Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progression in a melanoma mouse model. Moreover, we determined that BMP6 inhibits dermal mast cell recruitment and found that mast cell-derived mediators significantly reduced melanoma growth in vitro. In line with this, mast cell deficiency accelerated tumor onset and progression in a melanoma mouse model. Analysis of human melanoma tissues revealed a strong negative correlation between melanoma proliferation and mast cell infiltration. This study elucidates a novel role of BMP6-induced modulation of the tumor microenvironment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE MORPHOGENETIC PROTEINS; NECROSIS-FACTOR-ALPHA; MAST-CELLS; MELANOMA-CELLS; METABOTROPIC GLUTAMATE-RECEPTOR-1; HEPCIDIN EXPRESSION; MALIGNANT-MELANOMA; BMP6; REGULATOR; HISTAMINE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Apr 2020 08:37 |
| Last Modified: | 20 Apr 2020 08:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27692 |
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