Diagnostic performance of contrast-enhanced ultrasound (CEUS) in testicular pathologies: Single-center results

Lerchbaumer, Markus Herbert and Auer, Timo Alexander and Marticorena, Garcia Stephan and Stephan, Carsten and Hamm, Bernd and Jung, Ernst-Michael and Fischer, Thomas (2019) Diagnostic performance of contrast-enhanced ultrasound (CEUS) in testicular pathologies: Single-center results. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 73 (2). pp. 347-357. ISSN 1386-0291, 1875-8622

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Abstract

BACKGROUND: Contrast-enhanced ultrasound (CEUS) has been used as an additional imaging technique in order to clarify testicular findings. CEUS is easy and fast to perform, overcomes the limitations of B-mode US. OBJECTIVE: To evaluate the diagnostic performance of contrast-enhanced ultrasound (CEUS) in the assessment of unclear testicular pathologies. METHODS: CEUS examinations of 45 patients with unclear testicular pathologies between 2012 and 2018 were analyzed retrospectively. Examinations were performed using B-mode, colour Doppler (CCDS) and CEUS after injection of contrast agent (SonoVue (R), Bracco) and interpreted by an experienced radiologist (EFSUMB level 3). Reference standard was defined as histopathological report and clinical course. RESULTS: Overall 19 patients presented with a neoplastic lesion, whereas 14 were malignant. Matched to the histopathological report and clinical follow up, CEUS represented a sensitivity of 93% (95%-CI, 69-99), a specificity of 94% (95%-CI, 80-98), a positive predictive value (PPV) of 87% (95%-CI, 62-96) and a negative predictive value (NPV) of 97% (95%-CI, 83-99). CONCLUSION: CEUS is an accurate additional tool to differentiate between testicular alterations when B-mode US and CCDS are uncertain. CEUS may provide additional information and detect early enhancement in small tumor lesions when CCDS comes to its limit.

Item Type: Article
Uncontrolled Keywords: REAL-TIME ELASTOGRAPHY; MULTIPARAMETRIC US; COLOR DOPPLER; SONOGRAPHY; FEATURES; SCROTUM; SAFETY; TESTIS; MASSES; TUMORS; Contrast-enhanced ultrasound; CEUS; testis; testicular pathology
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Röntgendiagnostik
Depositing User: Dr. Gernot Deinzer
Date Deposited: 21 Apr 2020 05:55
Last Modified: 21 Apr 2020 05:55
URI: https://pred.uni-regensburg.de/id/eprint/27760

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