Spachmann, Philipp Julian and Breyer, Johannes and Kalogirou, Charis and Lausenmeyer, Eva-Maria and Weber, Florian and Prohaska, Sandra and Denzinger, Stefan and Burger, Maximilian and Kuebler, Hubert and Otto, Wolfgang and Vergho, Daniel (2019) Impact of E-Cadherin and beta-Catenin as Prognostic Factor in Renal Cell Carcinoma with Tumor Thrombus of the Vena Cava. UROLOGIA INTERNATIONALIS, 102 (4). pp. 413-420. ISSN 0042-1138, 1423-0399
Full text not available from this repository. (Request a copy)Abstract
Purpose: Renal cell carcinoma (RCC) forming tumor thrombus (TT) of vena cava (VC) is characterized by poor prognosis. Nevertheless, the outcome of patients after radical surgery varies. To date only limited data concerning prognostic biomarkers in this RCC subgroup are available. Methods: Out of 159 patients with pT3b/c RCC, 95 patients without synchronous distant metastases at time of diagnosis were included in the study cohort. After immunohistochemical (IHC) evaluation of E-cadherin and beta-Catenin expression, association with clinical, histopathological and survival was assessed by univariate analysis, multivariate analysis, and Kaplan-Meier-analysis. Cancer-specific survival (CSS) rates and overall survival (OS) rates were estimated using Kaplan-Meier analysis and compared using Log rank test. Results: We found a significant correlation between E-cadherin overexpression and initial lymph node metastasis (rho = 0.300, p = 0.003), positive surgical margins (rho = 0.210, p = 0.043), and the development of distant metastases (rho = 0.258, p = 0.012). Furthermore, we observed a significant correlation of beta-Catenin overexpression with higher tumor stage pT3c (rho = 0.230, p = 0.028) and initial lymph node metastases (rho = 0.236, p = 0.025). Survival analysis revealed a statistically significant association of both E-cadherin and beta-Catenin overexpression with worse CSS (p < 0.001 and p = 0.007, respectively) and OS (p < 0.001 and p = 0.041, respectively). Multivariate analysis revealed initial lymph node metastasis as the only predictive factor for worse OS (HR 4.54, 95% CI 2.30-8.93; p < 0.001). E-Cadherin and beta-Catenin expression failed to be significant in multivariable analysis for OS and CSS. Conclusions: In a large series of RCC with TT of VC high IHC expression of E-cadherin and beta-Catenin was associated with initial lymph node metastasis and with both worse OS and worse CSS. This might help to identify patients at risk for recurrence who might benefit from adjuvant therapy or stricter follow-up. (c) 2019 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INDEPENDENT PREDICTOR; EXPRESSION; CANCER; SURVIVAL; INVASION; PROLIFERATION; MANAGEMENT; MIGRATION; OUTCOMES; INSIGHT; Renal cell carcinoma; Vena cava infiltration; Tumor thrombus; E-cadherin; beta-Catenin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Apr 2020 09:35 |
| Last Modified: | 21 Apr 2020 09:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27802 |
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