Machado, Noelia D. and Fernandez, Mariana A. and Haering, Marleen and Saldias, Cesar and Diaz Diaz, David (2019) Niosomes encapsulated in biohydrogels for tunable delivery of phytoalexin resveratrol. RSC ADVANCES, 9 (14). pp. 7601-7609. ISSN 2046-2069,
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A series of biohydrogels based on mixtures of kappa-carrageenan (-carrageenan, -C) and gelatin were evaluated as potential soft delivery vehicles for the encapsulation and subsequent release of non-ionic surfactant vesicles (niosomes) loaded with resveratrol (RSV). The niosomes were prepared using a mixture of amphiphilic lipids Tween 80 and Span 80 in water. The results showed that RSV-niosomes did not significantly affect the hydrogelation properties of the biopolymer mixture. Moreover, in vitro drug release experiments from biohydrogels containing RSV-niosomes were successfully carried out under simulated gastrointestinal conditions. The RSV-niosomal liberation profiles from hydrogels were fitted using first order kinetics, Higuchi, Korsmeyer-Peppas and Weibull drug release models, showing the prevalence of diffusion mechanisms in each case. In addition, the RSV release was easily tuned by adjusting the total concentration of -C:gelatin. Interestingly, the niosomal-hydrogel system was also found to prevent the trans-to-cis photoisomerization of RSV.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-VITRO; BIOMEDICAL APPLICATIONS; TOPICAL DELIVERY; DRUG-DELIVERY; HYDROGELS; RELEASE; SYSTEM; BIOAVAILABILITY; LIPOSOMES; GEL; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Apr 2020 11:43 |
| Last Modified: | 21 Apr 2020 11:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27833 |
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