Pinkenburg, Olaf and Meyer, Torben and Bannert, Norbert and Norley, Steven and Bolte, Kathrin and Czudai-Matwich, Volker and Herold, Susanne and Gessner, Andre and Schnare, Markus (2016) The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus. PLOS ONE, 11 (6): e0156929. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
In addition to their well-known antibacterial activity some antimicrobial peptides and proteins (AMPs) display also antiviral effects. A 27 aa peptide from the N-terminal part of human bactericidal/permeability-increasing protein (BPI) previously shown to harbour antibacterial activity inhibits the infectivity of multiple Influenza A virus strains (H1N1, H3N2 and H5N1) the causing agent of the Influenza pneumonia. In contrast, the homologous murine BPI-peptide did not show activity against Influenza A virus. In addition human BPI-peptide inhibits the activation of immune cells mediated by Influenza A virus. By changing the human BPI-peptide to the sequence of the mouse homologous peptide the antiviral activity was completely abolished. Furthermore, the human BPI-peptide also inhibited the pathogenicity of the Vesicular Stomatitis Virus but failed to interfere with HIV and measles virus. Electron microscopy indicate that the human BPI-peptide interferes with the virus envelope and at high concentrations was able to destroy the particles completely.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GRAM-NEGATIVE BACTERIA; HUMAN ALPHA-DEFENSINS; REPLICATION; MECHANISMS; LL-37; SUBTYPES; PEPTIDE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Mar 2019 08:29 |
| Last Modified: | 22 Mar 2019 08:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2784 |
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