Schulz, Richard and Bischof, Fabian and Galetke, Wolfgang and Gall, Henning and Heitmann, Joerg and Hetzenecker, Andrea and Laudenburg, Markus and Magnus, Till Jonas and Nilius, Georg and Priegnitz, Christina and Randerath, Winfried and Schroeder, Maik and Treml, Marcel and Arzt, Michael (2019) CPAP therapy improves erectile function in patients with severe obstructive sleep apnea. SLEEP MEDICINE, 53. pp. 189-194. ISSN 1389-9457, 1878-5506
Full text not available from this repository. (Request a copy)Abstract
Objectives: Erectile dysfunction (ED) is highly prevalent in obstructive sleep apnea (OSA), however, the effect of continuous positive airway pressure (CPAP) therapy on erectile function has not yet been thoroughly investigated in these patients. Methods: Ninety-four men with severe OSA (ie, with an apnea-hypopnea-index >= 30/h of sleep) were prospectively evaluated for the presence and severity of ED before and after 6-12 months of CPAP therapy. The abbreviated version of the International Index of Erectile Function, (the IIEF-5) was used to rate erectile function. Furthermore, all study participants responded to standard questionnaires of daytime sleepiness (Epworth Sleepiness Scale), quality of life (WHO Wellbeing 5 questionnaire) and depression (Major Depression Inventory). Results: ED as defined by an IIEF-5 score of <= 21 was present in 64 patients (68.1%). CPAP treatment significantly improved erectile function in those patients suffering from moderate and severe ED. Additionally, a trend for a correlation between the improvement of erectile function under CPAP and the hours of its use was observed. Finally, this effect was associated with larger improvements of quality of life in affected patients. Conclusions: ED is very frequent in men with severe OSA and can at least partly be reversed by long-term CPAP therapy in most seriously affected patients. The beneficial effect on erectile function may depend on CPAP compliance and is accompanied by improvements of quality of life. Randomized controlled trials are needed to confirm these findings. (c) 2018 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSITIVE AIRWAY PRESSURE; SEXUAL FUNCTION; NASAL CPAP; DYSFUNCTION; MEN; ASSOCIATION; SILDENAFIL; MODEL; Sleep apnea; Erectile dysfunction; CPAP therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Apr 2020 06:43 |
| Last Modified: | 22 Apr 2020 06:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27883 |
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