Langguth, Berthold and Elgoyhen, Ana Belen and Cederroth, Christopher R. (2019) Therapeutic Approaches to the Treatment of Tinnitus. In: UNSPECIFIED Annual Review of Pharmacology and Toxicology,, 59 . ANNUAL REVIEWS, PALO ALTO, pp. 291-313. ISBN 978-0-8243-0459-1
Full text not available from this repository. (Request a copy)Abstract
Tinnitus is a highly prevalent condition that is associated with hearing loss in most cases. In the absence of external stimuli, phantom perceptions of sounds emerge from alterations in neuronal activity within central auditory and nonauditory structures. Pioneering studies using lidocaine revealed that tinnitus is susceptible to pharmacological interventions. However, lidocaine is not effective in all patients, and no other drug has been identified with clear efficacy for the long-term treatment of tinnitus. In this review, we present recent advances in tinnitus research, including more detailed knowledge of its pathophysiology and involved neurotransmitter systems. Moreover, we summarize results from animal and clinical treatment studies as well as from studies that identified tinnitus as a side effect of pharmacological treatments. Finally, we focus on challenges in the development of pharmacological compounds for the treatment of tinnitus, namely the limitations of available animal models and of standardized clinical research methodologies.
| Item Type: | Book Section |
|---|---|
| Uncontrolled Keywords: | ENRICHED ACOUSTIC ENVIRONMENT; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; HEARING-LOSS; COCHLEAR NUCLEUS; INFERIOR COLLICULUS; UNILATERAL TINNITUS; SUBJECTIVE TINNITUS; PERCEPTION TINNITUS; CLINICAL-TRIALS; tinnitus; phantom sound; hearing loss; plasticity; neural networks |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Medicine > Zentren des Universitätsklinikums Regensburg > Tinnituszentrum |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Apr 2020 05:01 |
| Last Modified: | 28 Apr 2020 05:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27885 |
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