Winter, Julia and Jurek, Ben (2019) The interplay between oxytocin and the CRF system: regulation of the stress response. CELL AND TISSUE RESEARCH, 375 (1). pp. 85-91. ISSN 0302-766X, 1432-0878
Full text not available from this repository. (Request a copy)Abstract
Oxytocin (OT) has drawn the attention of researchers since 1930. Since then, many aspects of oxytocin have been uncovered, such as reproductive functions, dampening anxiety, enhancing socioemotional behavior, or regulating genomic effects on a cellular level. Here, we want to focus on the interaction between the OT system and the stress/corticotropin-releasing factor (CRF)-system of the brain. Depending on the nature of the stressor, OT is released simultaneously or directly after the stress from the neurohypophysis into the periphery and/or via somato-dendritic release in stress-sensitive brain areas. This stress-induced OT release might serve to modulate or dampen the stress response; however, the functional relevance is not yet fully understood. In this review, we will describe the effects of OT and discuss the interplay between OT and CRF on a cellular, physiological, and behavioral level.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; BINDING-PROTEIN; BRAIN OXYTOCIN; PARAVENTRICULAR NUCLEUS; PARVOCELLULAR NEURONS; PERIPHERAL RELEASE; SUPRAOPTIC NUCLEUS; GABA(A) RECEPTORS; STRIA TERMINALIS; Oxytocin; Corticotropin releasing factor; Stress; HPA axis; PVN |
| Subjects: | 500 Science > 570 Life sciences 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Apr 2020 07:09 |
| Last Modified: | 22 Apr 2020 07:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27904 |
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