Grund, Thomas and Neumann, Inga D. (2019) Brain neuropeptide S: via GPCR activation to a powerful neuromodulator of socio-emotional behaviors. CELL AND TISSUE RESEARCH, 375 (1). pp. 123-132. ISSN 0302-766X, 1432-0878
Full text not available from this repository. (Request a copy)Abstract
Neuropeptide S (NPS) has attracted the attention of the scientific community due to its potent anxiolytic-like and fear-attenuating effects studied in rodents. Therefore, NPS might represent a treatment option for neuropsychiatric disorders, such as anxiety disorders, even more so as single nucleotide polymorphisms in the human NPS receptor gene have been associated with increased anxiety traits that contribute to the pathogenesis of fear- and anxiety-related disorders. However, the signaling mechanisms underlying the behavioral effects of NPS and the interaction with other brain neuropeptides are still rather unknown. To illuminate how NPS modulates the expression of selected emotional and social behaviors, the present review focuses on neuroanatomical and electrophysiological studies, as well as intracellular signaling mechanisms following NPS receptor stimulation in rodents. We will also discuss interactions of the NPS system with two well-described neuropeptides, namely corticotropin-releasing factor and oxytocin, which may contribute to the fear- and anxiety-reducing effects.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEIN-COUPLED RECEPTORS; LOCUS-COERULEUS; EXPRESSING NEURONS; REDUCES ANXIETY; PANIC DISORDER; FEAR; OXYTOCIN; MEMORY; MICE; PROJECTIONS; Neuropeptide S; Intracellular signaling; Anxiety; Fear; Neuromodulator |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 Mar 2020 07:26 |
| Last Modified: | 26 Mar 2020 07:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27905 |
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