Schicho, Andreas and Niessen, Christoph and Haimerl, Michael and Wiesinger, Isabel and Stroszczynski, Christian and Beyer, Lukas P. and Wiggermann, Philipp (2019) Long-term survival after percutaneous irreversible electroporation of inoperable colorectal liver metastases. CANCER MANAGEMENT AND RESEARCH, 11. pp. 317-322. ISSN 1179-1322,
Full text not available from this repository. (Request a copy)Abstract
Background: For colorectal liver metastases (CRLM) that are not amenable to surgery or thermal ablation, irreversible electroporation (IRE) is a novel local treatment modality and additional option. Methods: This study is a retrospective long-term follow-up of patients with CRLM who underwent IRE as salvage treatment. Results: Of the 24 included patients, 18(75.0%) were male, and the median age was 57 (range: 28-75) years. The mean time elapsed from diagnosis to IRE was 37.9 +/- 37.3 months. Mean overall survival was 26.5 months after IRE (range: 2.5-69.2 months) and 58.1 months after diagnosis (range: 14.8-180.1 months). One-, three-, and five-year survival rates after initial diagnosis were 100.0%, 79.2%, and 41.2%; after IRE, the respective survival rates were 79.1%, 25.0%, and 8.3%. There were no statistically significant differences detected in survival after IRE with respect to gender, age, T- or N-stage at the time of diagnosis, size of metastases subject to IRE, number of hepatic lesions, or time elapsed between IRE and diagnosis. Conclusion: For nonresectable CRLM, long-term survival data emphasize the value of IRE as a new minimally invasive local therapeutic approach in multimodal palliative treatment, which is currently limited to systemic or regional therapies in this setting.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOCAL TUMOR PROGRESSION; RADIOFREQUENCY ABLATION; SYSTEMIC CHEMOTHERAPY; CANCER; FLUOROURACIL; LEUCOVORIN; MANAGEMENT; MARGINS; MALIGNANCIES; OXALIPLATIN; liver metastases; survival; colorectal cancer; irreversible electroporation; long-term; salvage treatment; CRLM |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Apr 2020 08:23 |
| Last Modified: | 22 Apr 2020 08:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27934 |
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