Volz, Cornelia and Grassmann, Felix and Greslechner, Roman and Marker, David Arthur and Peters, Patrick and Helbig, Horst and Gamulescu, Maria-Andreea (2019) Spectral Domain Optical Coherence Tomography Allows the Unification of Clinical Decision Making for the Evaluation of Choroidal Neovascularization Activity. OPHTHALMOLOGICA, 241 (1). pp. 32-37. ISSN 0030-3755, 1423-0267
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Purpose: This prospective observational clinical study investigated the benefits of spectral domain optical coherence tomography for specialists and residents in the management of neovascular age-related macular degeneration (AMD). Procedures: The study involved 49 eyes of 44 patients. Patients were advised to present for reevaluation 4 weeks after the administration of the loading dose of vascular endothelial growth factor (VEGF)-inhibitors (3 intravitreal injections every 4 weeks after diagnosis). They were examined by residents (3-4 years' experience in ophthalmology) and specialists (> 5 years' experience). Each examiner evaluated the clinical situation and the spectral domain optical coherence tomography (SD-OCT) scan. After each evaluation, the examiners independently stated if further anti-VEGF treatment was recommended. The "true outcome" was defined as the specialist decision based on clinical evaluation and SD-OCT. Results: Specialists and residents did not significantly differ in their accuracy in deciding on the correct treatment (p = 0.705 and p = 1), with or without the aid of SD-OCT. Both groups benefited from using SD-OCT to support their recommendations (p = 0.001 and p = 0.0002) and achieved a similar level of accuracy (p = 1 for difference). Conclusions: Residents benefited more than specialists by using SD-OCT to substantiate their recommendation on how to manage exudative AMD after the administration of the loading dose. (C) 2018 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENDOTHELIAL GROWTH-FACTOR; MACULAR DEGENERATION; INTRAVITREAL RANIBIZUMAB; DOSING REGIMEN; BEVACIZUMAB; THERAPY; IMPACT; Neovascular age-related macular degeneration; Spectral Domain Optical Coherence Tomography; Anti-vascular endothelial growth factor therapy; Clinical decision-making |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Medicine > Lehrstuhl für Humangenetik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Apr 2020 08:36 |
| Last Modified: | 22 Apr 2020 08:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27940 |
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