Reinhold, S. W. and Uihlein, D. C. and Boeger, C. A. and Kloiber, S. and Froelich, K. and Bergler, T. and Banas, B. and Schweda, F. and Kraemer, B. K. (2009) RENIN, ENDOTHELIAL NO SYNTHASE AND ENDOTHELIN GENE EXPRESSION IN THE 2KIDNEY-1CLIP GOLDBLATT MODEL OF LONG-TERM RENOVASCULAR HYPERTENSION. EUROPEAN JOURNAL OF MEDICAL RESEARCH, 14 (12). pp. 520-525. ISSN 0949-2321,
Full text not available from this repository. (Request a copy)Abstract
Objective: Numerous reports have shown the influence of renin, nitric oxide (NO) and the endothelin (ET) systems for regulation of blood pressure and renal function. Furthermore, interactions between these peptides have been reported. Aim of our study was to investigate the relative contribution of these compounds in long-term renovascular hypertension / renal ischemia. Methods: Hypertension / left-sided renal ischemia was induced using the 2K1C-Goldblatt rat model. Renal renin, ET-1, ET-3 and endothelial NO synthase (eNOS) gene expression was measured by means of RNAse protection assay at different timepoints up to 10 weeks after induction of renal artery stenosis. Results: Plasma renin activity and renal renin gene expression in the left kidney were increased in the clipped animals while eNOS expression was unchanged. Furthermore, an increase in ET-1 expression and a decrease of ET 3 expression was detected in early stenosis. Conclusions: While renin is obviously involved in regulation of blood pressure and renal function in unilateral renal artery stenosis, ET-1, ET-3 and endothelium derived NO do not appear to play an important role in renal adaptation processes in long-term renal artery stenosis, although ET-1 and ET-3 might be involved in short-term adaptation processes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ONE-CLIP; NITRIC-OXIDE; ANGIOTENSIN SYSTEM; RENAL-HYPERTENSION; MESSENGER-RNA; 2-KIDNEY; RATS; KIDNEY; SECRETION; RECEPTOR; blood pressure; renin angiotensin system; nitric oxide; endothelins; long-term renal artery stenosis; RNAse protection assay |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Aug 2020 09:39 |
| Last Modified: | 27 Aug 2020 09:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27980 |
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