Pongratz, G. and Buttgereit, F. and Straub, Rainer H. (2009) The Circadian Rhythm in Rheumatic Diseases. AKTUELLE RHEUMATOLOGIE, 34 (6). pp. 370-374. ISSN 0341-051X, 1438-9940
Full text not available from this repository. (Request a copy)Abstract
Circadian rhythm refers to the periodic 24-h cycle that underlies many biological processes. In rheumatic disease, e.g., rheumatoid arthritis, circadian ups and downs of cytokine levels strongly correlate with daily fluctuations of symptoms, like morning stiffness or pain. This review gives a short overview regarding circadian rhythms in general and in the context of rheumatic disease, like rheumatoid arthritis. The hypothesis is introduced that clinical efficacy of anti-inflammatory treatment for rheumatoid arthritis is dependent on the time of the day when the medication is used. Clinical implications of this hypothesis are discussed in detail. In summary, it is shown that the anti-inflammatory potential is increased when anti-inflammatory drugs, like glucocorticoids, are released about 2.00 in the morning and not the evening before.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARTHRITIS; RAT; rheumatoid arthritis; cicadian rhythm; anti-inflammatory drugs; glucocorticoids; timed drug release |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 29 Nov 2022 06:59 |
| Last Modified: | 29 Nov 2022 06:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/27995 |
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