Chang, Ya-Yi and Greinix, Hildegard T. and Dickinson, Anne M. and Wolff, Daniel and Jackson, Graham H. and Andreesen, Reinhard and Holler, Ernst and Hildebrandt, Gerhard C. (2009) G to C transition at position-173 of MIF gene of the recipient is associated with reduced relapse rates after allogeneic stem cell transplantation. CYTOKINE, 48 (3). pp. 218-225. ISSN 1043-4666, 1096-0023
Full text not available from this repository. (Request a copy)Abstract
Pro-inflammatory and dendritic cell-activating properties of macrophage migration inhibitory factor (MIF) suggest a potentially important role for MIF in alloantigen-specific immune responses after allogeneic stem cell transplantation (allo-SCT). We tested whether MIF - 173 G/C gene polymorphism of donor or patient had impacts on the outcomes after allo-SCT. Four hundred and fifty-four donor-patient pairs were genotyped and mortality, relapse, and development of complications were analyzed. Patient but not donor MIF-173*C allele was associated with improved overall survival (OS) (5 years: 60.8% versus 46.3%, p = 0.042) and disease free survival (DFS) (5 years: 55.4% versus 39.5%; p = 0.014) due to a reduction in relapse (day 2000: 22.8% versus 42.0% p = 0.006) but not due to decreased transplantation-related mortality (TRM) (p = 0.44). Muitivariate analysis proved patient - 173*C allele as an indepepdent factor for reducing relapse after allo-SCT (p = 0.023). Subgroup analysis showed a clear MIF-173*C allele-related reduction in relapse for those patients who did not receive T cell depleted (TCD) SCT (p = 0.01) in contrast to patients receiving TCD SCT (p = 0.20). In summary, patient MIF-173*C allele may be linked to specific, yet unrevealed functions in tumor biology and graft versus leukemia and lymphoma effects and potentially presents a novel prognostic marker for patient-tailored counseling and therapy in allo-SCT. (C) 2009 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MIGRATION-INHIBITORY FACTOR; VERSUS-HOST-DISEASE; ANTIGEN-PRESENTING CELLS; JUVENILE IDIOPATHIC ARTHRITIS; BONE-MARROW-TRANSPLANTATION; PROSTATE-CANCER; T-CELLS; POLYMORPHISMS ASSOCIATE; ALLOANTIGEN EXPRESSION; RHEUMATOID-ARTHRITIS; Allogeneic; Stem cell transplantation; MIF; Polymorphism; Relapse |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Aug 2020 12:38 |
| Last Modified: | 27 Aug 2020 12:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28015 |
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