Bouazzaoui, A. and Spacenko, E. and Mueller, G. and Miklos, S. and Huber, E. and Holler, E. and Andreesen, R. and Hildebrandt, G. C. (2009) Chemokine and chemokine receptor expression analysis in target organs of acute graft-versus-host disease. GENES AND IMMUNITY, 10 (8). pp. 687-701. ISSN 1466-4879, 1476-5470
Full text not available from this repository. (Request a copy)Abstract
Acute graft-versus-host disease (aGVHD) is a major complication after allogeneic bone marrow transplantation (allo-BMT), and infiltration of donor leukocytes into aGVHD target organs is partially orchestrated by chemokines. Using a murine BMT model, the expression of 30 chemokines or chemokine receptors in the lung, liver, gut and tongue was analyzed using real-time PCR at 1, 2, 3 and 6 weeks after BMT during the development of clinical aGVHD and target organ histopathology. CXCL9-11 expression was linked to elevated expression of CXCR3 in the gut, lung and tongue. In contrast, hepatic CXCR3 expression was not changed, whereas a clear association was seen for CXCL16 and CXCR6 expression. An elevated intestinal CCL3 expression 1 week after allo-BMT was associated with an increased expression of CCR5 but not CCR1 or CCR3, and in the lung and liver CCL3-CCL5 expression was associated with increases in CCR1 and CCR5. Overexpression of CCL2, CCL8, CCL12 and their receptor CCR2 was found in the liver and lung, but not in the gut and tongue. On the basis of the differences in kinetics and organ distribution, more studies are required to better characterize specific targets within this network, as this will allow the development of novel preventive and therapeutic approaches by using single or multiple targeting reagents. Genes and Immunity (2009) 10, 687-701; doi: 10.1038/gene.2009.49; published online 2 July 2009
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IDIOPATHIC PNEUMONIA SYNDROME; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; SECONDARY LYMPHOID ORGANS; ALLOREACTIVE T-CELLS; GENE-EXPRESSION; DENDRITIC CELLS; IN-VIVO; IFN-GAMMA; SIGNIFICANTLY CONTRIBUTES; stem cell transplantation; graft-versus-host disease; chemokine; chemokine receptor; leukocyte recruitment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Aug 2020 06:43 |
| Last Modified: | 31 Aug 2020 06:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28028 |
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