Korte, Gabriele and Dreiseitel, Andrea and Schreier, Peter and Oehme, Anett and Locher, Sanja and Hajak, Goeran and Sand, Philipp G. (2009) An Examination of Anthocyanins' and Anthocyanidins' Affinity for Cannabinoid Receptors. JOURNAL OF MEDICINAL FOOD, 12 (6). pp. 1407-1410. ISSN 1096-620X, 1557-7600
Full text not available from this repository. (Request a copy)Abstract
A growing body of evidence suggests that anthocyanins and anthocyanidins may possess analgesic properties in addition to neuroprotective and anti-inflammatory activities. These functionalities suggest a role for the cannabinoid receptor (CB) in mediating biological effects. Competitive radioligand binding assays identified cyanidin (K-i = 16.2 mu M) and delphinidin (K-i = 21.3 mu M) as ligands with moderate affinity to human CB1. For CB2, similar affinities were achieved by cyanidin (K-i = 33.5 mu M), delphinidin (K-i = 34.3 mu M), and peonidin (K-i = 46.4 mu M). Inhibition constants > 50 mu M were obtained for pelargonidin, malvidin, cyanidin-3,5-di-O-glucoside, cyanidin-3-O-glucoside, cyanidin-3-O-galactoside, and cyanidin-3-O-rutinoside for both CB subtypes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CB2 RECEPTOR; BRAIN; RATS; PAIN; MICE; EXTRACT; DIET; ANTIOXIDANT; EXPRESSION; CYANIDIN; anthocyanidin; anthocyanin; cannabinoid receptor; pain; inflammation; neuroprotection |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Aug 2020 08:47 |
| Last Modified: | 31 Aug 2020 08:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28056 |
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