Mack, Matthias and Rosenkranz, Alexander R. (2009) Basophils and mast cells in renal injury. KIDNEY INTERNATIONAL, 76 (11). pp. 1142-1147. ISSN 0085-2538
Full text not available from this repository. (Request a copy)Abstract
Until recently, basophils and mast cells were considered mainly effector cells with an innate immune response linked to allergy and parasite infection. Only in the past few years they were recognized as important regulators of adaptive immunity. The development of new methods and reagents has enabled detection and functional analysis of these rare cells in patients and murine disease models. Basophils are normally present in the peripheral blood, spleen, and bone marrow, but migrate into lymph nodes and tissues during inflammation. They are rapidly activated by cytokines (e. g., interleukin (IL)-3) and intact antigens that cross-link surface-bound immunoglobulins. Activated basophils change the phenotype of T cells toward Th2 and markedly support humoral memory responses. Mast cells also migrate into lymph nodes and interact with dendritic cells, T cells, and B cells. In this review, we describe how mast cells and basophils affect immune responses and discuss implications for renal diseases and transplant rejection. Kidney International (2009) 76, 1142-1147; doi:10.1038/ki.2009.320; published online 19 August 2009
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IDENTIFICATION; GLOMERULONEPHRITIS; RESPONSES; IMMUNITY; INTERLEUKIN-3; IRRADIATION; TOLERANCE; MICE; SKIN; basophils; glomerulonephritis; kidney; mast cells; T cells; transplant rejection |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Petra Gürster |
| Date Deposited: | 29 Nov 2022 08:00 |
| Last Modified: | 29 Nov 2022 08:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28063 |
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