Hume, David A. and Summers, Kim M. and Rehli, Michael (2016) Transcriptional Regulation and Macrophage Differentiation. MICROBIOLOGY SPECTRUM, 4 (3): UNSP MCHD-. ISSN 2165-0497,
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Monocytes and macrophages are professional phagocytes that occupy specific niches in every tissue of the body. Their survival, proliferation, and differentiation are controlled by signals from the macrophage colony-stimulating factor receptor (CSF-1R) and its two ligands, CSF-1 and interleukin-34. In this review, we address the developmental and transcriptional relationships between hematopoietic progenitor cells, blood monocytes, and tissue macrophages as well as the distinctions from dendritic cells. A huge repertoire of receptors allows monocytes, tissue-resident macrophages, or pathology-associated macrophages to adapt to specific microenvironments. These processes create a broad spectrum of macrophages with different functions and individual effector capacities. The production of large transcriptomic data sets in mouse, human, and other species provides new insights into the mechanisms that underlie macrophage functional plasticity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLONY-STIMULATING FACTOR; MONONUCLEAR PHAGOCYTE SYSTEM; HEMATOPOIETIC STEM-CELLS; TISSUE-RESIDENT MACROPHAGES; GENE-EXPRESSION PROFILES; DENDRITIC CELLS; MONOCYTE SUBSETS; IN-VIVO; STEADY-STATE; C-FMS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Mar 2019 09:11 |
| Last Modified: | 22 Mar 2019 09:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2807 |
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