Lefevre, Stephanie and Knedla, Anette and Tennie, Christoph and Kampmann, Andreas and Wunrau, Christina and Dinser, Robert and Korb, Adelheid and Schnaeker, Eva-Maria and Tarner, Ingo H. and Robbins, Paul D. and Evans, Christopher H. and Stuerz, Henning and Steinmeyer, Juergen and Gay, Steffen and Schoelmerich, Juergen and Pap, Thomas and Mueller-Ladner, Ulf and Neumann, Elena (2009) Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. NATURE MEDICINE, 15 (12). 1414-U10. ISSN 1078-8956, 1546-170X
Full text not available from this repository. (Request a copy)Abstract
Active rheumatoid arthritis originates from few joints but subsequently affects the majority of joints. Thus far, the pathways of the progression of the disease are largely unknown. As rheumatoid arthritis synovial fibroblasts (RASFs) which can be found in RA synovium are key players in joint destruction and are able to migrate in vitro, we evaluated the potential of RASFs to spread the disease in vivo. To simulate the primary joint of origin, we implanted healthy human cartilage together with RASFs subcutaneously into severe combined immunodeficient (SCID) mice. At the contralateral flank, we implanted healthy cartilage without cells. RASFs showed an active movement to the naive cartilage via the vasculature independent of the site of application of RASFs into the SCID mouse, leading to a marked destruction of the target cartilage. These findings support the hypothesis that the characteristic clinical phenomenon of destructive arthritis spreading between joints is mediated, at least in part, by the transmigration of activated RASFs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENDOTHELIAL-CELL ADHESION; GENE-TRANSFER; IN-VITRO; CARTILAGE; DESTRUCTION; MIGRATION; SYNOVIOCYTES; PATHOGENESIS; OSTEOARTHRITIS; PROLIFERATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Aug 2020 09:37 |
| Last Modified: | 31 Aug 2020 09:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28070 |
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