Botella, Jose A. and Bayersdorfer, Florian and Gmeiner, Florian and Schneuwly, Stephan (2009) Modelling Parkinson's Disease in Drosophila. NEUROMOLECULAR MEDICINE, 11 (4). pp. 268-280. ISSN 1535-1084, 1559-1174
Full text not available from this repository. (Request a copy)Abstract
The recent discovery of a number of genes involved in familial forms of Parkinson's disease (PD) has moved the use of model genetic organisms to the frontline. One avenue holding tremendous potential to find therapies against human diseases is the use of intact living systems where complex biological processes can be examined. Despite key differences that need to be taken into account when using invertebrate models such as Drosophila, there are many advantages offered by this system. The rapid generation time and the ability to easily generate transgenic animals together with the variety of genetic tools to control temporal and spatial expression of any given gene makes the fly model a very attractive system to study human neurodegenerative disorders. In this review, we analyze how the use of fruit flies has revealed to be an excellent tool providing valuable insights into the current understanding of the molecular mechanisms involved in the progression of PD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DOPAMINERGIC NEURON DEGENERATION; ALPHA-SYNUCLEIN AGGREGATION; TARGETED GENE-EXPRESSION; OXIDATIVE STRESS; DJ-1 MUTANTS; MITOCHONDRIAL PATHOLOGY; TYROSINE-HYDROXYLASE; CELL-DEATH; MUTATIONS; PATHWAY; Parkinson's disease; Drosophila; alpha-Synuclein; Parkin; PINK1; Rotenone; Oxidative stress |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 29 Nov 2022 08:02 |
| Last Modified: | 29 Nov 2022 08:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28077 |
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