Tomm, Manuel and Koch, Arend and Mertsch, Sonja and Wrede, Brigitte and Jeibmann, Astrid and Wolff, Johannes and Paulus, Werner and Hasselblatt, Martin (2009) Role of Wnt Inhibitory Factor-1 and Wnt/Wingless Signaling in Choroid Plexus Tumors. PEDIATRIC BLOOD & CANCER, 53 (6). pp. 1152-1155. ISSN 1545-5009, 1545-5017
Full text not available from this repository. (Request a copy)Abstract
Little is known on pathways involved in the pathogenesis of choroid plexus tumors (CPTs). The finding of overexpression of Wnt inhibitory factor-1 (Wif-1) prompted us to investigate the functional role of Wif-1 as well as nuclear accumulation of beta-catenin in CPT. In Z310 neoplastic choroid plexus epithelial cells, silencing of Wif1 expression increased proliferative activity not associated with increased canonical Wnt signaling. Nuclear beta-catenin accumulation was also lacking in a series of 16 CPT. In conclusion, our data show that Wif-1 inhibits proliferation of neoplastic choroid plexus epithelial cells, but argue against a role of canonical Wnt/wingless signaling in CPT. Pediatr Blood Cancer 2009;53:1152-1155. (C) 2009 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EPIGENETIC INACTIVATION; BLADDER-CANCER; PATHWAY; MEDULLOBLASTOMAS; PROLIFERATION; COMPONENT; CELLS; beta-catenin; choroid plexus carcinoma; choroid plexus papilloma; pathogenesis; Wif-1 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Aug 2020 09:45 |
| Last Modified: | 31 Aug 2020 09:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28080 |
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