Bateman, E. D. and Rennard, S. and Barnes, P. J. and Dicpinigaitis, P. V. and Gosens, R. and Gross, N. J. and Nadel, J. A. and Pfeifer, M. and Racke, K. and Rabe, K. F. and Rubin, B. K. and Welte, T. and Wessler, I. (2009) Alternative mechanisms for tiotropium. PULMONARY PHARMACOLOGY & THERAPEUTICS, 22 (6). pp. 533-542. ISSN 1094-5539,
Full text not available from this repository. (Request a copy)Abstract
Tiotropium is commonly used in the treatment of chronic obstructive pulmonary disease. Although largely considered to be a long-acting bronchodilator, its demonstrated efficacy in reducing the frequency of exacerbations and preliminary evidence from early studies indicating that it might slow the rate of decline in lung function suggested mechanisms of action in addition to simple bronchodilation. This hypothesis was examined in the recently published UPLIFT study and, although spirometric and other clinical benefits of tiotropium treatment extended to four years, the rate of decline in lung function did not appear to be reduced by the addition of tiotropium in this study. This article summarizes data from a variety of investigations that provide insights into possible mechanisms to account for the effects of tiotropium. The report summarizes the discussion on basic and clinical research in this field. (c) 2009 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AIRWAY SMOOTH-MUSCLE; OBSTRUCTIVE PULMONARY-DISEASE; BRONCHIAL EPITHELIAL-CELLS; POLYSPECIFIC CATION TRANSPORTERS; NONNEURONAL CHOLINERGIC SYSTEM; RECEPTORS MEDIATE STIMULATION; LUNG FIBROBLAST PROLIFERATION; MUCOCILIARY CLEARANCE; IPRATROPIUM BROMIDE; ANTICHOLINERGIC BRONCHODILATOR; Tiotropium; COPD; Mechanisms; Inflammation; Remodelling; Mucus; Cough |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Aug 2020 12:39 |
| Last Modified: | 31 Aug 2020 12:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28091 |
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