Paulus, Christina and Nevels, Michael (2009) The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses. VIRUSES-BASEL, 1 (3). pp. 760-779. ISSN 1999-4915
Full text not available from this repository. (Request a copy)Abstract
The major immediate-early (IE) gene of human cytomegalovirus (CMV) is believed to have a decisive role in acute infection and its activity is an important indicator of viral reactivation from latency. Although a variety of gene products are expressed from this region, the 72-kDa IE1 and the 86-kDa IE2 nuclear phosphoproteins are the most abundant and important. Both proteins have long been recognized as promiscuous transcriptional regulators. More recently, a critical role of the IE1 and IE2 proteins in counteracting non-adaptive host cell defense mechanisms has been revealed. In this review we will briefly summarize the available literature on IE1- and IE2-dependent mechanisms contributing to CMV evasion from intrinsic and innate immune responses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; LOW-MULTIPLICITY INFECTION; IE2 86-KILODALTON PROTEIN; LEUKEMIA NUCLEAR-BODIES; CELL-CYCLE PROGRESSION; VIRAL GENE-EXPRESSION; IE86 PROTEIN; FUNCTIONAL INTERACTION; RETINOBLASTOMA PROTEIN; cytomegalovirus; CMV; innate immunity; intrinsic defense; interferon response; nuclear domain 10; apoptosis; immediate-early genes; IE1; IE2 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 29 Nov 2022 09:50 |
| Last Modified: | 29 Nov 2022 09:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28101 |
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