Gaebele, Erwin and Muehlbauer, Marcus and Paulo, Hartwig and Johann, Monika and Meltzer, Christin and Leidl, Franz and Wodarz, Norbert and Wiest, Reiner and Schoelmerich, Juergen and Hellerbrand, Claus (2009) Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis. WORLD JOURNAL OF GASTROENTEROLOGY, 15 (44). pp. 5558-5562. ISSN 1007-9327, 2219-2840
Full text not available from this repository. (Request a copy)Abstract
AIM: To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1) gene in patients with spontaneous bacterial peritonitis (SBP). METHODS: MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites. RESULTS: The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However, in the subgroup of patients with alcoholic cirrhosis (n = 80), carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%, P = 0.021). CONCLUSION: In patients with alcoholic liver cirrhosis, the -2518 MCP-1 genotype AA is a risk factor for the development of SBP. (C) 2009 The WJG Press and Baishideng. All rights reserved
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MONOCYTE CHEMOATTRACTANT PROTEIN-1; ENDOTHELIAL GROWTH-FACTOR; NITRIC-OXIDE PRODUCTION; CIRRHOTIC-PATIENTS; LIVER-DISEASE; MCP-1 GENE; PROMOTER POLYMORPHISM; ACUTE-INFLAMMATION; REGULATORY REGION; UP-REGULATION; Monocyte chemotactic protein-1; Chemokines; Spontaneous bacterial peritonitis; Polymorphism; Liver cirrhosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Sep 2020 11:01 |
| Last Modified: | 01 Sep 2020 11:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28107 |
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