Hohl, Tobias M. and Rivera, Amariliz and Lipuma, Lauren and Gallegos, Alena and Shi, Chao and Mack, Mathias and Pamer, Eric G. (2009) Inflammatory Monocytes Facilitate Adaptive CD4 T Cell Responses during Respiratory Fungal Infection. CELL HOST & MICROBE, 6 (5). pp. 470-481. ISSN 1931-3128, 1934-6069
Full text not available from this repository. (Request a copy)Abstract
Aspergillus fumigatus, a ubiquitous fungus, causes invasive disease in immunocompromised humans. Although monocytes and antigen-specific CD4 T cells contribute to defense against inhaled fungal spores, how these cells interact during infection remains undefined. Investigating the role of inflammatory monocytes and monocyte-derived dendritic cells during fungal infection, we find that A. fumigatus infection induces an influx of chemokine receptor CCR2- and Ly6C-expressing inflammatory monocytes into lungs and draining lymph nodes. Depletion of CCR2(+) cells reduced A. fumigatus conidial transport from lungs to draining lymph nodes, abolished CD4 T cell priming following respiratory challenge, and impaired pulmonary fungal clearance. In contrast, depletion of CCR2(+)Ly6C(hi) monocytes during systemic fungal infection did not prevent CD4 T cell priming in the spleen. Our findings demonstrate that pulmonary CD4 T cell responses to inhaled spores require CCR2(+)Ly6C(hi) monocytes and their derivatives, revealing a compartmentally restricted function for these cells in adaptive respiratory immune responses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INVASIVE PULMONARY ASPERGILLOSIS; DENDRITIC CELLS; HOST-DEFENSE; BONE-MARROW; MYCOBACTERIUM-TUBERCULOSIS; BACTERIAL-INFECTION; CHEMOKINE RECEPTOR; FUMIGATUS CONIDIA; IMMUNE-RESPONSES; BLOOD MONOCYTES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Sep 2020 05:14 |
| Last Modified: | 02 Sep 2020 05:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28127 |
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