Weber, Markus and Sporrer, Daniela and Weigert, Johanna and Wanninger, Josef and Neumeier, Markus and Wurm, Sylvia and Stoegbauer, Fabian and Kopp, Andrea and Bala, Margarita and Schaeffler, Andreas and Buechler, Christa (2009) Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes. FEBS LETTERS, 583 (22). pp. 3718-3724. ISSN 0014-5793,
Full text not available from this repository. (Request a copy)Abstract
Galectin-3 plays a role in atherosclerotic diseases, and the effect of adiponectin that protects from atherosclerotic diseases on monocytic galectin-3 was analysed. Adiponectin reduced galectin-3 mRNA, its cellular and soluble form, and this effect was impaired in T2D cells. Cellular galectin-3 was higher in monocytes of overweight than normal-weight donors and was highest in T2D cells. Cellular galectin-3 positively correlated with the BMI of the donors and negatively with soluble monocyte galectin-3. Circulating levels of total adiponectin did not correlate with cellular or soluble galectin-3 indicating that additional factors contribute to higher cellular monocytic galectin-3 in obesity and T2D. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INSULIN-RESISTANCE; METABOLIC SYNDROME; IL-6 PRODUCTION; PROTEIN-KINASE; DEFICIENT MICE; INFLAMMATION; MACROPHAGES; ACTIVATION; RECEPTOR; PATHWAY; Type 2 diabetes mellitus; Obesity; Adiponectin; Galectin-3; Monocyte |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Sep 2020 05:16 |
| Last Modified: | 02 Sep 2020 05:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28128 |
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