Pellegrino, Sara and Ferri, Nicola and Colombo, Noemi and Cremona, Edoardo and Corsini, Alberto and Fanelli, Roberto and Gelmi, Maria Luisa and Cabrele, Chiara (2009) Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19 (22). pp. 6298-6302. ISSN 0960-894X, 1464-3405
Full text not available from this repository. (Request a copy)Abstract
Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated alpha-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of alpha-actin and decreased Id protein levels. (C) 2009 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOOP-HELIX DOMAIN; DNA-BINDING; IN-VIVO; HOMODIMERIZATION; ATHEROSCLEROSIS; DIFFERENTIATION; EXPRESSION; FRAGMENTS; CANCER; E47; Id proteins; Protein domain recognition; Helix-loop-helix; Peptide dimerization; Peptide mimic; Solid-phase peptide synthesis; Smooth muscle cell |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Alumni or Retired Professors > Arbeitskreis Dr. Chiara Cabrele |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Sep 2020 05:21 |
| Last Modified: | 02 Sep 2020 05:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28131 |
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