Knott, Juergen Manfred (2009) Biosynthesis of long-chain polyamines by crenarchaeal polyamine synthases from Hyperthermus butylicus and Pyrobaculum aerophilum. FEBS LETTERS, 583 (21). pp. 3519-3524. ISSN 0014-5793,
Full text not available from this repository. (Request a copy)Abstract
Polyamines are ubiquitously present in all organisms. In addition to the common polyamines, thermophilic archaea synthesize long-chain polyamines. In the present study polyamine synthases from Hyperthermus butylicus and Pyrobaculum aerophilum were cloned and their substrate specificity was analyzed. The polyamine synthase HbSpeE II from H. butylicus synthesized long-chain polyamines with high activity using the same mechanism that is used by a wide range of organisms to synthesize common polyamines, in which the aminopropyl residue derives from decarboxylated S-adenosylmethionine. This is the first polyamine synthase described that synthesizes a polyamine longer than a tetramine with high activity. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXTREME THERMOPHILE; ARABIDOPSIS-THALIANA; THERMUS-THERMOPHILUS; SPERMIDINE SYNTHASE; ARCHAEBACTERIUM; THERMOSPERMINE; TRANSFERASE; PYROCOCCUS; Long-chain polyamine; Archaea; Polyamine synthesis; Hyperthermus butylicus; Pyrobaculum aerophilum |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Sep 2020 05:51 |
| Last Modified: | 02 Sep 2020 05:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28154 |
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