Schuster, Kerstin and Gadiot, Jules and Andreesen, Reinhard and Mackensen, Andreas and Gajewski, Thomas F. and Blank, Christian (2009) Homeostatic proliferation of naive CD8(+) T cells depends on CD62L/L-selectin-mediated homing to peripheral LN. EUROPEAN JOURNAL OF IMMUNOLOGY, 39 (11). pp. 2981-2990. ISSN 0014-2980,
Full text not available from this repository. (Request a copy)Abstract
Adoptive transfer of naive CD8(+) T cells into lymphopenic recipients results both in spontaneous proliferation and in partial activation of T cells, a phenomenon termed homeostatic proliferation (HP). HP of CD8(+) T cells is dependent on host IL-7, IL-15, and MHC-class I and has been shown to prevent T-cell tolerance, reverse T-cell anergy and support T-cell-mediated tumor control in vivo. However, the initial anatomic site of HP is still under debate. Since we observed that the earliest detectable HP occurs within LN and that T cells undergoing HP retain a CD62L bright phenotype, we investigated the functional role of CD62L for this process. We found that CD62L-expression on T cells is required for optimal HP and HP was impaired in lymphotoxin-alpha beta(-/-) mice, indicating the necessity for intact host secondary lymphoid organ structures. Use of the LN egression inhibitor FTY720 indicated that LN structures were pivotal to yield homeostatically proliferated T cells detected in other compartments. Consistent with these results, HP-supported control of MC57-SIY tumors depended on CD62L. Our data indicate a critical role for CD62L and LN homing for the process of HP, which has implications for adoptive immunotherapy approaches of cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SELECTIN-DEFICIENT MICE; CUTTING EDGE; CANCER REGRESSION; TRANSFER THERAPY; IRRADIATED MICE; MEMORY; CD4; AUTOIMMUNITY; LYMPHODEPLETION; EXPANSION; Cell homing; Homeostasis; T cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Sep 2020 08:28 |
| Last Modified: | 02 Sep 2020 08:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28180 |
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