Riese, Christoph G. U. and Seitz, Stephan and Schipper, Meike L. and Behr, Thomas M. (2009) Effective treatment of pancreatic neuroendocrine tumours transfected with the sodium iodide symporter gene by Re-186-perrhenate in mice. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 36 (11). pp. 1767-1773. ISSN 1619-7070,
Full text not available from this repository. (Request a copy)Abstract
ReO (4) (-) has similar kinetics regarding the sodium iodide symporter (NIS) to I- and TcO (4) (-) in NIS-expressing tissue. We investigated the therapeutic potential of (ReO)-Re-186 (4) (-) in NIS-transfected neuroendocrine tumour tissue. For experiments, the stably NIS-transfected pancreatic neuroendocrine cancer cell line Bon1C was used. NIS-mediated internalization and externalization experiments in vitro and a biodistribution study in nude mice bearing Bon1C xenografts were performed. A therapy study was also conducted consecutively in nude mice xenografted with Bon1C in which the mice were injected intravenously with (NaReO4)-Re-186. In vitro studies showed exponential internalization and efflux kinetics of (ReO)-Re-186 (4) (-) in the cell line. The biodistribution study showed high uptake of (ReO)-Re-186 (4) (-) in NIS-expressing tumours. Tumour growth inhibition was significant after injection of (ReO4)-Re-186 in two groups of animals treated with activity levels below the determined maximum tolerable activity as compared to controls. These results indicate that the use of (ReO)-Re-186 (4) (-) in the treatment of NIS-expressing neuroendocrine tumours is feasible and support the concept of using NIS as a therapeutic target for (ReO)-Re-186 (4) (-) .
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CANCER CELL-LINES; SODIUM/IODIDE-SYMPORTER; NA+/I-SYMPORTER; IN-VIVO; SALIVARY-GLAND; BREAST-CANCER; TC-99M PERTECHNETATE; PROSTATE-CANCER; GASTRIC-MUCOSA; MAMMARY-GLAND; Sodium iodide symporter; Re-186-Perrhenate; Rhenium-186; Neuroendocrine tumours; Radionuclide therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Sep 2020 08:38 |
| Last Modified: | 02 Sep 2020 08:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28183 |
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