Kohl, E. and Landthaler, M. and Szeimies, R. -M. (2009) Skin aging. HAUTARZT, 60 (11). pp. 917-933. ISSN 0017-8470, 1432-1173
Full text not available from this repository.Abstract
Like the entire human organism, the skin is subject to an intrinsic unpreventable aging process. But exogenous factors also influence skin aging. Ultraviolet radiation in particular results in premature skin aging, also referred to as extrinsic skin aging or photo aging, causing in large part aging-associated changes in sun-exposed areas. Intrinsic and extrinsic aging share several molecular similarities despite morphological and pathophysiological differences. The formation of reactive oxygen species and the induction of metalloproteinases reflect central aspects of skin aging. Accumulation of fragmented collagen fibrils prevents neocollagenesis and accounts for further degradation of extracellular matrix by means of positive feedback regulation. The importance of extrinsic factors in skin aging and the detection of its mechanisms has given rise to development of various therapeutic and preventive strategies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ULTRAVIOLET-B IRRADIATION; IN-VIVO; PROTEIN OXIDATION; HUMAN EPIDERMIS; AGED SKIN; DAMAGE; PHOTOPROTECTION; MELANOGENESIS; PATHOGENESIS; DEGRADATION; Matrix metalloproteinases; Intrinsic skin aging; Extrinsic skin aging; Photo aging; UV iradiation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Sep 2020 08:41 |
| Last Modified: | 02 Sep 2020 08:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28189 |
Actions (login required)
 |
View Item |
