Barlage, Stefan and Gnewuch, Carsten and Liebisch, Gerhard and Wolf, Zsuzsanna and Audebert, Franz-Xaver and Glueck, Thomas and Froehlich, Dieter and Kraemer, Bernhard K. and Rothe, Gregor and Schmitz, Gerd (2009) Changes in HDL-associated apolipoproteins relate to mortality in human sepsis and correlate to monocyte and platelet activation. INTENSIVE CARE MEDICINE, 35 (11). pp. 1877-1885. ISSN 0342-4642, 1432-1238
Full text not available from this repository. (Request a copy)Abstract
Lipoproteins modulate vascular cell function in inflammation. In this study, we analyzed whether plasma concentrations of lipoproteins and apolipoproteins in human sepsis are related to patient survival and the activation of blood monocytes and platelets. Observational study. Medical and surgical intensive care units (ICU) of a university hospital. 151 consecutive patients after sepsis criteria had been met for the first time. None. Plasma lipoproteins, apolipoproteins, platelet CD62P-expression, monocyte HLA-DR-expression, SAPS II-scores (Simplified Acute Physiology Score) and 30-day-mortality were recorded. Total cholesterol, high-density-lipoprotein (HDL) and low-density-lipoprotein (LDL) cholesterol, apolipoprotein (apo)-AI and apo-B were all found to be significantly lower in non-survivors than in survivors. In contrast to other (apo)lipoproteins, apo-AI and HDL cholesterol further decreased in non-survivors during the ICU stay. Logistic regression analysis revealed apo-AI to be an independent predictor of 30-day-mortality. A significant inverse correlation was found for apo-AI/HDL-cholesterol and platelet activation. Later in the course of the disease, HLA-DR expression on monocytes correlated positively to apo-AI and apo-CI concentrations and inversely to the apo-E concentration. Low apo-AI is independently related to 30-day mortality in human sepsis and the decrease in apo-AI/HDL cholesterol correlates to increased platelet activation. Moreover, changes in apolipoproteins supposed to modulate lipopolysaccharide effects, such as apo-CI and apo-E, correlate to monocyte activation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIGH-DENSITY-LIPOPROTEIN; INFLAMMATORY RESPONSE; A-I; MENINGOCOCCAL SEPSIS; DISEASE SEVERITY; STATIN THERAPY; SERUM-LIPIDS; EX-VIVO; LIPOPOLYSACCHARIDE; CHOLESTEROL; Sepsis; HDL; Apolipoprotein; Platelet; Monocyte |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Sep 2020 09:06 |
| Last Modified: | 02 Sep 2020 09:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28196 |
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