Hanses, Frank and Zierhut, S. and Schoelmerich, J. and Salzberger, B. and Wrede, C. E. (2009) Severe and long lasting cholestasis after high-dose co-trimoxazole treatment for Pneumocystis pneumonia in HIV-infected patients-a report of two cases. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 13 (6). E467-E469. ISSN 1201-9712,
Full text not available from this repository. (Request a copy)Abstract
Pneumocystis pneumonia (PCP), a common opportunistic infection in HIV-infected individuals, is generally treated with high doses of co-trimoxazole. However, treatment is often limited by adverse effects. Here, we report two cases of severely immunocompromised HIV-infected patients who developed severe intrahepatic cholestasis, and in one patient lesions mimicking liver abscess formation on radiologic exams, during co-trimoxazole treatment for PCP. Whereas patient 1 showed lesions of up to 1 cm readily detectable on magnetic resonance imaging under prolonged co-trimoxazole treatment, therapy of patient 2 was switched early. (C) 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BILE-DUCT SYNDROME; TRIMETHOPRIM-SULFAMETHOXAZOLE; CARINII-PNEUMONIA; ADVERSE-REACTIONS; AIDS; TRIMETHOPRIM/SULFAMETHOXAZOLE; PANCREATITIS; LIVER; HIV; Pneumocystis pneumonia; Trimethoprim-sulfamethoxazole; Adverse effects; Intrahepatic cholestasis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Sep 2020 09:09 |
| Last Modified: | 02 Sep 2020 09:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28198 |
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