Egan, C. E. and Craven, M. D. and Leng, J. and Mack, M. and Simpson, K. W. and Denkers, E. Y. (2009) CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection. MUCOSAL IMMUNOLOGY, 2 (6). pp. 527-535. ISSN 1933-0219, 1935-3456
Full text not available from this repository. (Request a copy)Abstract
Mice of the C57BL/6 strain develop acute ileal inflammation after infection with the protozoan parasite Toxoplasma gondii. This pathology resembles many key features of human Crohn's disease, including a Th1 cytokine profile with high levels of interferon gamma(IFN-gamma), interleukin 12 (IL)-12, and tumor necrosis factor alpha(TNF)-alpha, presence of pathogenic CD4(+) T cells, and infiltration of gut flora into inflammed tissue. Using CCR2(-/-) mice, we identify a role for this chemokine receptor in the pathogenesis of inflammatory pathology during T. gondii infection. Lack of chemokine (C-C motif) receptor 2 (CCR2) was associated with low levels of CD103(+) T lymphocytes in the intraepithelial compartment, Peyer's patch, and lamina propria relative to wild-type animals. Adoptive transfer of wild-type, but not IFN-gamma(-/-), intraepithelial T lymphocytes converted CCR2 knockout mice from a resistant to susceptible phenotype with respect to parasite-triggered inflammatory gut pathology. These results for the first time show a role for intraepithelial T lymphocytes in pathogenesis of ileitis triggered by a microbial pathogen.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTESTINAL EPITHELIAL-CELLS; CD4(+) T-LYMPHOCYTES; COMPLEX CLASS-I; CROHNS-DISEASE; BOWEL-DISEASE; ESCHERICHIA-COLI; ORAL INFECTION; DEFICIENT MICE; MURINE ILEITIS; ILEAL MUCOSA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Sep 2020 13:42 |
| Last Modified: | 02 Sep 2020 13:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28220 |
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