Zausig, York A. and Zink, Wolfgang and Keil, Meike and Sinner, Barbara and Barwing, Juergen and Wiese, Christoph H. R. and Graf, Bernhard M. (2009) Lipid Emulsion Improves Recovery from Bupivacaine-Induced Cardiac Arrest, but Not from Ropivacaine- or Mepivacaine-Induced Cardiac Arrest. ANESTHESIA AND ANALGESIA, 109 (4). pp. 1323-1326. ISSN 0003-2999,
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND: Cardiac toxicity significantly correlates with the lipophilicity of local anesthetics (LAs). Recently, the infusion of lipid emulsions has been shown to be a promising approach to treat LA-induced cardiac arrest. As the postulated mechanism of action, the so-called "lipid sink" effect may depend on the lipophilicity of LAs. In this study, we investigated whether lipid effects differ with regard to the administered LAs. METHODS: In the isolated rat heart, cardiac arrest was induced by administration of equipotent doses of bupivacaine, ropivacaine, and mepivacaine, respectively, followed by cardiac perfusion with or without lipid emulsion (0.25 mL . kg(-1) . min(-1)). Subsequently, the times from the start of perfusion to return of first heart activity and to recovery of heart rate and rate-pressure product (to 90% of baseline values) were assessed. RESULTS: In all groups, lipid infusion had no effects on the time to the return of any cardiac activity. However, recovery times of heart rate and rate-pressure product (to 90% of baseline values) were significantly shorter with the administration of lipids in bupivacaine-induced cardiac toxicity, but not in ropivacaine- or mepivacaine-induced cardiac toxicity. CONCLUSIONS: These data show that the effects of lipid infusion on LA-induced cardiac arrest are strongly dependent on the administered LAs itself. We conclude that lipophilicity of LAs has a marked impact on the efficacy of lipid infusions to treat cardiac arrest induced by these drugs. (Anesth Analg 2009;109:1323-6)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ISOLATED RAT-HEART; SUCCESSFUL RESUSCITATION; LOCAL-ANESTHETICS; INDUCED ASYSTOLE; PLEXUS BLOCK; INFUSION; TOXICITY; LEVOBUPIVACAINE; OVERDOSE; THERAPY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Sep 2020 09:25 |
| Last Modified: | 03 Sep 2020 09:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28286 |
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