Niemeyer, P. and Albrecht, D. and Andereya, S. and Angele, P. and Ateschrang, A. and Aurich, M. and Baumann, M. and Bosch, U. and Erggelet, C. and Fickert, S. and Gebhard, H. and Gelse, K. and Guenther, D. and Hoburg, A. and Kasten, P. and Kolombe, T. and Madry, H. and Marlovits, S. and Meenen, N. M. and Mueller, P. E. and Noeth, U. and Petersen, J. P. and Pietschmann, M. and Richter, W. and Rolauffs, B. and Rhunau, K. and Schewe, B. and Steinert, A. and Steinwachs, M. R. and Welsch, G. H. and Zinser, W. and Fritz, J. (2016) Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU). KNEE, 23 (3). pp. 426-435. ISSN 0968-0160, 1873-5800
Full text not available from this repository. (Request a copy)Abstract
Background: Autologous chondrocyte implantation (ACI) is an established and well-accepted procedure for the treatment of localised full-thickness cartilage defects of the knee. Methods: The present review of the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU) describes the biology and function of healthy articular cartilage, the present state of knowledge concerning therapeutic consequences of primary cartilage lesions and the suitable indication for AU Results: Based on best available scientific evidence, an indication for ACI is given for symptomatic cartilage defects starting from defect sizes of more than three to four square centimetres; in the case of young and active sports patients at 2.5 cm(2), while advanced degenerative joint disease needs to be considered as the most important contraindication. Conclusion: The present review gives a concise overview on important scientific background and the results of clinical studies and discusses the advantages and disadvantages of ACI. (C) 2016 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RANDOMIZED CONTROLLED-TRIAL; BILAYER COLLAGEN MEMBRANE; BONE-MARROW STIMULATION; MESENCHYMAL STEM-CELLS; 2-YEAR FOLLOW-UP; ARTICULAR-CARTILAGE; CHONDRAL DEFECTS; SUBCHONDRAL BONE; OSTEOCHONDRAL DEFECTS; MICROFRACTURE TECHNIQUE; Knee joint; Cartilage defect; Cartilage repair; Recommendations; Osteoarthritis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 02 Sep 2020 06:37 |
| Last Modified: | 02 Sep 2020 06:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2829 |
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