Grauer, Oliver M. and Wesseling, Pieter and Adema, Gosse J. (2009) Immunotherapy of Diffuse Gliomas: Biological Background, Current Status and Future Developments. BRAIN PATHOLOGY, 19 (4). pp. 674-693. ISSN 1015-6305, 1750-3639
Full text not available from this repository. (Request a copy)Abstract
Despite aggressive multimodal treatment approaches, the prognosis for patients with diffuse gliomas remains disappointing. Glioma cells often extensively infiltrate in the surrounding brain parenchyma, a phenomenon that helps them to escape surgical removal, radiation exposure and chemotherapy. Moreover, conventional therapy is often associated with considerable local and systemic side effects. Therefore, the development of novel therapeutic approaches is essential to improve the outcome of these patients. Immunotherapy offers the opportunity to specifically target residual radio-and chemoresistant tumor cells without damaging healthy neighboring brain tissue. Significant progress has been made in recent years both in understanding the mechanisms of immune regulation in the central nervous system (CNS) as well as tumor-induced and host-mediated immunosuppression elicited by gliomas. In this review, after discussing the special requirements needed for the initiation and control of immune responses in the CNS, we focus on immunological phenomena observed in glioma patients, discuss different immunological approaches to attack glioma-associated target structures and touch on further strategies to improve the efficacy of immunotherapy of gliomas.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; CENTRAL-NERVOUS-SYSTEM; PULSED DENDRITIC CELLS; GROWTH-FACTOR-BETA; BLOOD-BRAIN-BARRIER; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ANTITUMOR IMMUNE-RESPONSES; MYELOID SUPPRESSOR-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; HEMATOPOIETIC PROGENITOR CELLS; central nervous system; dendritic cell; glioma; immune escape; immunotherapy; vaccine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 07 Nov 2024 10:41 |
| Last Modified: | 07 Nov 2024 10:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28297 |
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