Leitzmann, Michael F. and Flood, Andrew and Ferrucci, Leah M. and Schoenfeld, Philip and Cash, Brooks and Schatzkin, Arthur and Cross, Amanda J. (2009) Adiposity in relation to colorectal adenomas and hyperplastic polyps in women. CANCER CAUSES & CONTROL, 20 (8). pp. 1497-1507. ISSN 0957-5243,
Full text not available from this repository. (Request a copy)Abstract
Objective To examine whether BMI is independently related to colorectal adenomas and hyperplastic polyps. Methods We conducted a cross-sectional study among 1,420 asymptomatic women aged 40-79 years who had undergone complete colonoscopy. Logistic regression was used to estimate the odds ratios (OR) and the corresponding 95% confidence intervals (CI) of adenomas and hyperplastic polyps. Results We identified 953 women (67.1%) with no polyps, 292 (20.6%) with adenomas, and 175 (12.3%) with hyperplastic polyps. Among those with polyps, 75 women (5.3% of total women) were classified as having both adenomas and hyperplastic polyps. After adjusting for potential risk factors for colorectal cancer, BMI was related to increased risk of adenomas (OR comparing obese to normal weight women = 1.57; 95% CI = 1.07-2.29). Further, BMI was associated with enhanced risk of hyperplastic polyps (OR = 3.76; 95% CI = 2.35-6.01) and the combination of adenomas and hyperplastic polyps (OR = 2.84; 95% CI = 1.41-5.72). Conclusions Excess body mass is positively related to colorectal adenomas and hyperplastic polyps, particularly when both kinds of polyps are present in combination. Future studies should continue to delineate the possible differences in potential risk factors between colorectal adenomas and hyperplastic polyps. Such work should help further elucidate the possible causes of colorectal cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BODY-MASS INDEX; PHYSICAL-ACTIVITY; RISK-FACTORS; SIGMOID COLON; LARGE-BOWEL; LIFE-STYLE; ASYMPTOMATIC INDIVIDUALS; CARCINOMA SEQUENCE; INSULIN-RESISTANCE; CIGARETTE-SMOKING; Adiposity; Obesity; Colorectal adenoma; Hyperplastic polyps; Women |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Sep 2020 12:05 |
| Last Modified: | 03 Sep 2020 12:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28303 |
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