Buchholz, Stefan and Seitz, Stephan and Schally, Andrew V. and Engel, Joerg B. and Rick, Ferenc G. and Szalontay, Luca and Hohla, Florian and Krishan, Awtar and Papadia, Andrea and Gaiser, Timo and Brockhoff, Gero and Ortmann, Olaf and Diedrich, Klaus and Koester, Frank (2009) Triple-negative breast cancers express receptors for luteinizing hormone-releasing hormone (LHRH) and respond to LHRH antagonist Cetrorelix with growth inhibition. INTERNATIONAL JOURNAL OF ONCOLOGY, 35 (4). pp. 789-796. ISSN 1019-6439, 1791-2423
Full text not available from this repository. (Request a copy)Abstract
The aim of the present study was to evaluate the expression of receptors for luteinizing hormone-releasing hormone (LHRH) in human specimens of triple-negative breast cancers (TNBC). In addition, we used in vitro and in vivo models of TNBC to investigate if these receptors are suitable targets for the treatment with the LHRH antagonist Cetrorelix. Receptors for LHRH were expressed in all tumor samples and in the TNBC cell lines HCC1806 and HCC1937. The proliferation of both TNBC cell lines was significantly inhibited in vitro by I mu M Cetrorelix. Injections of 3 mg Cetrorelix on day I and 21 resulted in a significant growth inhibition of HCC1806 tumors xenografted into nude mice. Tumors of mice treated with Cetrorelix expressed less mRNA for EGFR and HER3 receptors than untreated tumors. After treatment of cells with Cetrorelix a flow cytometric analysis of the cell cycle revealed a decrease in S-phase. Given the low toxicity and clinical availability of Cetrorelix, this peptide antagonist should be considered for phase II studies in patients with advanced TNBC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIGH-AFFINITY BINDING; OVARIAN-CANCER; CELL-LINES; GNRH AGONISTS; NUDE-MICE; ANALOGS; RH; THERAPY; CARCINOMA; MARKERS; triple-negative breast cancer; LHRH antagonist; LHRH receptor; xenografted mouse model; cell cycle analysis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Sep 2020 06:42 |
| Last Modified: | 04 Sep 2020 06:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28348 |
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