Rupprecht, Korbinian and Schmidt, Christoph and Raspe, Anne and Schweda, Frank and Shipkova, Maria and Fischer, Wolfgang and Bucher, Michael and Kees, Frieder and Faerber, Lothar (2009) Bioavailability of Mycophenolate Mofetil and Enteric-Coated Mycophenolate Sodium Is Differentially Affected by Pantoprazole in Healthy Volunteers. JOURNAL OF CLINICAL PHARMACOLOGY, 49 (10). pp. 1196-1201. ISSN 0091-2700, 1552-4604
Full text not available from this repository. (Request a copy)Abstract
The influence of pantoprazole 40 mg twice daily on the bio-availability of a single dose of mycophenolate mofetil 1000 mg or enteric-coated mycophenolate sodium is investigated in healthy volunteers. The plasma concentrations of mycophenolic acid and of the inactive metabolite mycophenolic acid glucuronide are measured by high-performance liquid chromatography. The pharmacokinetic parameters following sole administration are similar for mycophenolate mofetil and enteric-coated mycophenolate sodium except for the time to peak concentration, which is longer in the enteric-coated mycophenolate sodium group. Concomitant treatment with pantoprazole significantly (P < .001) lowers the mycophenolic acid exposure following administration of mycophenolate mofetil. The peak concentrations drop by 57%, and area under the curve decreases from 0 to 12 hours by 27%. In contrast, pantoprazole does not change the pharmacokinetics of enteric-coated mycophenolate sodium. Given that mycophenolic acid exposure correlates with the incidence of biopsy-proven acute rejections in renal transplant recipients, these findings may have clinical implications. Administration of pantoprazole in combination with mycophenolate mofetil could possibly result in an insufficient mycophenolic acid exposure, increasing the risk of treatment failure.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTON PUMP INHIBITORS; RENAL-TRANSPLANTATION; GLUCURONIDE METABOLITE; HUMAN PLASMA; CALCINEURIN INHIBITORS; ACID PHARMACOKINETICS; CYCLOSPORINE; RECIPIENTS; TACROLIMUS; IMPAIRMENT; Proton pump inhibitor; drug-drug interaction; mycophenolic acid; pharmacokinetics; high-performance liquid chromatography |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 615 Pharmacy |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Frieder Kees |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Sep 2020 06:51 |
| Last Modified: | 04 Sep 2020 06:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28355 |
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