Sontag, Thomas A. and Lange, Klaus W. and Heim, Christine and Kolasiewicz, Waclav and Tucha, Oliver and Sontag, Karl-Heinz (2009) Alterations of nocturnal activity in rats following subchronic oral administration of the neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline. JOURNAL OF NEURAL TRANSMISSION, 116 (10). pp. 1267-1271. ISSN 0300-9564, 1435-1463
Full text not available from this repository. (Request a copy)Abstract
1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) is neurotoxic when administered to the brain and alters motor behaviour following intraperitoneal administration. We have assessed the long-term effects of oral TaClo administration on nocturnal motor behaviour in rats. Two groups of rats received TaClo orally at a dose of either 0.2 or 0.4 mg/kg twice daily for 7 weeks. The control group was given saline. No change in locomotor activity was observed 4-9 days after the end of the 7-week administration of TaClo. In addition, the spontaneous motor activity was altered dose-dependently 9 months after oral TaClo administration, with an increase in the low-dose TaClo group and a decrease in the high-dose group. Oral administration of TaClo in rats may be useful in investigating the hypothesis that in Parkinson's disease, an unknown pathogenic factor crossing the intestinal mucosa barrier can induce neurodegenerative processes eventually affecting the entire brain.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PARKINSONS-DISEASE; TACLO; 1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline; TaClo; Oral administration; Motor behaviour; Nocturnal activity; Rat; Parkinson's disease |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Sep 2020 06:54 |
| Last Modified: | 04 Sep 2020 06:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28358 |
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