Schmidt-Wilcke, Tobias and Poljansky, Stefan and Hierlmeier, Stefanie and Hausner, Joachim and Ibach, Bernd (2009) Memory performance correlates with gray matter density in the ento-/perirhinal cortex and posterior hippocampus in patients with mild cognitive impairment and healthy controls - A voxel based morphometry study. NEUROIMAGE, 47 (4). pp. 1914-1920. ISSN 1053-8119,
Full text not available from this repository. (Request a copy)Abstract
Voxel based morphometry (VBM) is a useful tool to assess differences in brain morphology between groups of patients and healthy controls. In addition, VBM enables the performance of regression analyses to determine potential correlations between performance on cognitive tests and variations in local brain morphology. Prior VBM studies investigating patients with mild cognitive impairment (MCI) have revealed different patterns of local brain atrophy. In order to extend previous findings, we investigated 18 patients with MCI and 18 age- and gender-matched healthy controls. All participants underwent extensive neuropsychological testing in addition to undergoing anatomical scanning with magnetic resonance imaging (MRI). Cohort analysis revealed bilateral decreases in gray matter density in the medial temporal lobes (MTLs) and neocortical regions of the temporal lobes in patients with MCI. Moreover, regression analyses demonstrated a correlation between immediate verbal recall and gray matter density in the left perirhinal/entorhinal cortex, while delayed free recall correlated with gray matter density in the left hippocampus. It has been proposed that performance in the immediate recall is supported by the so-called "episodic buffer", a component of working memory that contributes to the maintenance of integrated memory traces. Accordingly, our results suggest that anatomical regions associated with verbal long-term and verbal working memory are structurally segregated within the left MTL (C) 2009 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MEDIAL TEMPORAL-LOBE; PROGRESSIVE MULTIPLE-SCLEROSIS; VERBAL EPISODIC MEMORY; ALZHEIMERS-DISEASE; WORKING-MEMORY; FUNCTIONAL NEUROANATOMY; PREFRONTAL CORTEX; SCREENING-TEST; PET; ATROPHY; Mild cognitive impairment; Hippocampus long-term memory; Working memory; Voxel based morphometry |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Sep 2020 08:45 |
| Last Modified: | 04 Sep 2020 08:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28365 |
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