Steinbauer, Julia and Schreml, Stephan and Karrer, Sigrid and Ackermann, Guenther and Babilas, Philipp and Landthaler, Michael and Szeimies, Rolf-Markus (2009) Phototoxic reactions in healthy volunteers following photodynamic therapy with methylaminolevulinate cream or with cream containing 5-aminolevulinic acid: a phase II, randomized study. PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 25 (5). pp. 270-275. ISSN 0905-4383, 1600-0781
Full text not available from this repository. (Request a copy)Abstract
Background: Photodynaminc therapy (PDT) is the selective destruction of abnormal cells through activation of a photosensitizer in the presence of oxygen. Local phototoxic reactions and pain are the most common limiting side effects. Purpose: The primary objective was to compare the local phototoxic response following PDT with methylaminolevulinate (MAL) and 5-aminolevulinic acid (ALA). The secondary objectives were to compare the two treatments regarding pain, detection of substance P, change in fluorescence intensity from before to 5 h after cream application and adverse events not related to local phototoxicity. Methods: Thirty-four healthy volunteers were treated by PDT using MAL 160 mg/g cream and ALA cream 20% randomly assigned to treatment areas on the inside of each upper arm. A composite score of local phototoxic events (erythema, edema, hyperpigmentation) was calculated. Results: The area under the curve (AUC) analysis of composite scores showed a significantly higher AUC for ALA-PDT (P <= 0.0001). ALA- and MAL-PDT showed equivalent local side-effect frequencies, except for a higher frequency of hyperpigmentation after 28 d using ALA-PDT (P = 0.006). Conclusion: MAL- and ALA-PDT are nearly equivalent regarding individual side-effect frequencies, but MAL-PDT has a more favorable phototoxicity pattern as seen by AUC analysis and the lower frequency of long-lasting hyperpigmentation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NONMELANOMA SKIN-CANCER; ACTINIC KERATOSES; METHYL AMINOLEVULINATE; PORPHYRIN FLUORESCENCE; BOWENS-DISEASE; PAIN; DERMATOLOGY; MULTICENTER; GUIDELINES; UPDATE; aminolevulinic acid; methylaminolevulinate; pain; photodynamic therapy; phototoxicity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Sep 2020 08:52 |
| Last Modified: | 04 Sep 2020 08:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28369 |
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