Scott, Neil W. and Fayers, Peter M. and Aaronson, Neil K. and Bottomley, Andrew and de Graeff, Alexander and Groenvold, Mogens and Gundy, Chad and Koller, Michael and Petersen, Morten A. and Sprangers, Mirjam A. G. (2009) The practical impact of differential item functioning analyses in a health-related quality of life instrument. QUALITY OF LIFE RESEARCH, 18 (8). pp. 1125-1130. ISSN 0962-9343, 1573-2649
Full text not available from this repository. (Request a copy)Abstract
Differential item functioning (DIF) analyses are commonly used to evaluate health-related quality of life (HRQoL) instruments. There is, however, a lack of consensus as to how to assess the practical impact of statistically significant DIF results. Using our previously published ordinal logistic regression DIF results for the Fatigue scale of a HRQoL instrument as an example, the practical impact on a particular Norwegian clinical trial was investigated. The results were used to determine the difference in mean Fatigue scores assuming that the same trial was conducted in the UK. The results were then compared with published information on what would be considered a clinically important change in scores. The item with the largest DIF effect resulted in differences between the mean English and Norwegian Fatigue scores that, although small, could be considered clinically important. Sensitivity analyses showed that larger differences were found for shorter scales, and when the proportions in each response category were equal. Our scenarios suggest that translation differences in an item can result in small, but clinically important, differences at the scale score level. This is more likely to be problematic for observational studies than for clinical trials, where randomised groups are stratified by centre.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EORTC QLQ-C30; Differential item functioning; Quality of life; Clinical importance; Clinical trials |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Sep 2020 05:21 |
| Last Modified: | 07 Sep 2020 05:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28380 |
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