Bauhuber, Sonja and Hozsa, Constantin and Breunig, Miriam and Goepferich, Achim (2009) Delivery of Nucleic Acids via Disulfide-Based Carrier Systems. ADVANCED MATERIALS, 21 (32-33). pp. 3286-3306. ISSN 0935-9648, 1521-4095
Full text not available from this repository. (Request a copy)Abstract
Nucleic acids are not, only expected to assume a pivotal position as "drugs" in the treatment of genetic and acquired diseases, but could also act as molecular cues to control the microenvironment during tissue regeneration. Despite this promise, the efficient delivery of nucleic acids to their side of action is still the major hurdle. One among many prerequisites for a successful carrier system for nucleic acids is high stability in the extracellular environment, accompanied by an efficient release of the cargo in the intracellular compartment. In this review, emphasis is placed on the biological rationale for the synthesis of redox sensitive, disulfide-based carrier intracellular compartments. In this review, emphasis is placed on the biological rationale for the synthesis of redox sensitive, disulfide-based carrier systems, as well as the extra- and intracellular processing of macromolecules containing disulfide bonds. Moreover, the basic synthetic approaches for introducing disulfide bonds into carrier molecules, together with examples that demonstrate the benefit of disulfides at the individual stages of nucleic acid delivery, will be presented.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NONVIRAL GENE DELIVERY; POLY-L-LYSINE; TRIGGERED INTRACELLULAR ACTIVATION; BIOREDUCIBLE POLY(AMIDO AMINE)S; IN-VITRO CHARACTERIZATION; CROSS-LINKED POLYPLEXES; THIOL REDUCTASE GILT; PLASMID DNA; POLYETHYLENE-GLYCOL; TRANSGENE EXPRESSION |
| Subjects: | 600 Technology > 600 Technology (Applied sciences) 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 23 May 2024 06:27 |
| Last Modified: | 23 May 2024 06:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28415 |
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