Bain, Calum C. and Hawley, Catherine A. and Garner, Hannah and Scott, Charlotte L. and Schridde, Anika and Steers, Nicholas J. and Mack, Matthias and Joshi, Anagha and Guilliams, Martin and Mowat, Allan Mc I. and Geissmann, Frederic and Jenkins, Stephen J. (2016) Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities. NATURE COMMUNICATIONS, 7: 11852. ISSN 2041-1723,
Full text not available from this repository. (Request a copy)Abstract
Peritoneal macrophages are one of the most studied macrophage populations in the body, yet the composition, developmental origin and mechanisms governing the maintenance of this compartment are controversial. Here we show resident F4/80(hi)GATA6(+) macrophages are long-lived, undergo non-stochastic self-renewal and retain cells of embryonic origin for at least 4 months in mice. However, Ly6C(+) monocytes constitutively enter the peritoneal cavity in a CCR2-dependent manner, where they mature into short-lived F4/80(lo)MHCII(+) cells that act, in part, as precursors of F4/80(hi)GATA6(+) macrophages. Notably, monocyte-derived F4/80(hi) macrophages eventually displace the embryonic population with age in a process that is highly gender dependent and not due to proliferative exhaustion of the incumbent embryonic population, despite the greater proliferative activity of newly recruited cells. Furthermore, although monocyte-derived cells acquire key characteristics of the embryonic population, expression of Tim4 was impaired, leading to cumulative changes in the population with age.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TISSUE-RESIDENT MACROPHAGES; HEMATOPOIETIC STEM-CELLS; DENDRITIC CELLS; PERITONEAL-MACROPHAGES; CIRCULATING MONOCYTES; ALVEOLAR MACROPHAGES; CARDIAC MACROPHAGES; ACUTE-INFLAMMATION; FETAL MONOCYTES; STEADY-STATE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Mar 2019 09:44 |
| Last Modified: | 22 Mar 2019 09:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2842 |
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